Primary Identifier | MGI:3043469 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Ptpn22 |
Transmission | Germline | Strain of Origin | Not Specified |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exon 8, encoding the phosphatase domain, was replaced with a neo cassette via homologous recombination. Immunoblot analysis confirmed the absence of wild-type or truncated protein in thymocytes and splenocytes from homozygotes. |