Primary Identifier | MGI:97723 | Organism | mouse, laboratory |
Chromosome | 19 | NCBI Gene Number | 18946 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable lipase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; heart; and respiratory system. Orthologous to human PNLIPRP1 (pancreatic lipase related protein 1). PHENOTYPE: Mice homozygous for a knock-out allele show increased lipase activity in pancreatic juice and develop obesity associated with increased body fat mass, impaired glucose tolerance and insulin resistance, with these conditions exacerbated on a high-fat diet. [provided by MGI curators] |