| First Author | Wu Z | Year | 2013 |
| Journal | Genes Dev | Volume | 27 |
| Issue | 2 | Pages | 157-62 |
| PubMed ID | 23348839 | Mgi Jnum | J:193485 |
| Mgi Id | MGI:5468609 | Doi | 10.1101/gad.203406.112 |
| Citation | Wu Z, et al. (2013) Tricornered/NDR kinase signaling mediates PINK1-directed mitochondrial quality control and tissue maintenance. Genes Dev 27(2):157-62 |
| abstractText | Eukaryotes employ elaborate mitochondrial quality control (MQC) to maintain the function of the power-generating organelle. Parkinson's disease-associated PINK1 and Parkin actively participate in MQC. However, the signaling events involved are largely unknown. Here we show that mechanistic target of rapamycin 2 (mTORC2) and Tricornered (Trc) kinases act downstream from PINK1 to regulate MQC. Trc is phosphorylated in mTORC2-dependent and mTORC2-independent manners and is specifically localized to mitochondria in response to PINK1, which regulates mTORC2 through mitochondrial complex-I activity. Genetically, mTORC2 and Trc act upstream of Parkin. Thus, multiplex kinase signaling is acting between PINK1 and Parkin to regulate MQC, a process highly conserved in mammals. |
