| First Author | Pflanz S | Year | 2002 |
| Journal | Immunity | Volume | 16 |
| Issue | 6 | Pages | 779-90 |
| PubMed ID | 12121660 | Mgi Jnum | J:77522 |
| Mgi Id | MGI:2181922 | Doi | 10.1016/s1074-7613(02)00324-2 |
| Citation | Pflanz S, et al. (2002) IL-27, a Heterodimeric Cytokine Composed of EBI3 and p28 Protein, Induces Proliferation of Naive CD4(+) T Cells. Immunity 16(6):779-90 |
| abstractText | An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed IL-27 that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4(+) T cells. It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR. |
