| First Author | Sprecher CA | Year | 1998 |
| Journal | Biochem Biophys Res Commun | Volume | 246 |
| Issue | 1 | Pages | 82-90 |
| PubMed ID | 9600072 | Mgi Jnum | J:47617 |
| Mgi Id | MGI:1203845 | Doi | 10.1006/bbrc.1998.8576 |
| Citation | Sprecher CA, et al. (1998) Cloning and characterization of a novel class I cytokine receptor. Biochem Biophys Res Commun 246(1):82-90 |
| abstractText | The human gp130 cDNA sequence was used as a query to search an expressed sequence tag database (dbEST) to identify cDNA sequences with similarity to the cytokine class I receptor family. A novel class I cytokine receptor was identified in a human infant brain cDNA library and was named WSX-1. Full-length cDNA sequences for human and murine WSX-1 were isolated and characterized. The WSX-1 cDNA encodes a 636 amino acid transmembrane protein with an extracellular domain of 482 amino acids and a cytoplasmic domain of 96 amino acids. The structure of the WSX-1 protein most closely resembles that of gp130. Northern blot analysis indicates high levels of expression in thymus, spleen, lymph node, and peripheral blood leukocytes, suggesting a role for WSX-1 in modulation of the immune response. |
