| Primary Identifier | IPR030737 | Type | Family |
| Short Name | IQSEC1 |
| description | IQ motif and SEC7 domain-containing protein 1 (IQSEC1), also known as Arf-GEP100 or BRAG2, is a GEF (guanine nucleotide exchange factor) for Arf6 GTPase. In addition to Arf6, endogenous BRAG2 also activates the class II Arfs, Arf4 and Arf5. It acts at clathrin-coated pits to promote integrin internalization by activating Arf [, ]. It regulates phagocytosis of monocytic phagocytes in an ARF6-dependent process []and is involved in the apoptotic cell death of monocytic phagocytes []. |
