| First Author | Pernas-Alonso R | Year | 1995 |
| Journal | Neuroreport | Volume | 6 |
| Issue | 4 | Pages | 597-600 |
| PubMed ID | 7605908 | Mgi Jnum | J:25043 |
| Mgi Id | MGI:72757 | Doi | 10.1097/00001756-199503000-00003 |
| Citation | Pernas-Alonso R, et al. (1995) Acetylcholine esterase and peripherin mRNA level decrease in wobbler mouse. Neuroreport 6(4):597-600 |
| abstractText | Homozygote wobbler mice develop motoneurone degeneration. Throughout development the expression of choline acetyltransferase, of trkC receptor and F3 adhesion molecule genes is similar in wobbler and wild-type spinal cord. Acetylcholinesterase mRNA level instead is decreased to about 50% with respect to wild-type values in one forth of P5 and P10 wobbler progeny, putative wr/wr individuals; at P21 its expression is equally highly reduced in known homozygotes and it is reduced to 35% of normal values in about one half of the progeny, putative heterozygotes. Thus, similarly to medium neurofilament gene over-expression, reduced acetylcholinesterase gene expression is an early molecular marker for the wobbler mutation before onset of the illness. |
