| Primary Identifier | MGI:1354170 | Organism | mouse, laboratory |
| Chromosome | 10 | NCBI Gene Number | 100503659 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables transmembrane transporter binding activity. Involved in negative regulation of calcium ion transmembrane transport and negative regulation of calcium ion-dependent exocytosis. Located in plasma membrane and secretory granule. Colocalizes with growth cone. Is expressed in nervous system. Orthologous to human CBARP (CACN subunit beta associated regulatory protein). PHENOTYPE: Mice homozygous for a knock-out allele show alterations in presynaptic striatal nicotinic acetylcholine receptors and reduced persistent nicotine-induced dopamine release in striatal synaptosomes. Homozygous KO also leads to lower body weight, reduced grip strength, hypoactivity, increased sociability, decreased startle reflex and enhanced spatial working memory. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
