| Primary Identifier | MGI:1858751 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 54170 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including GTPase binding activity; guanyl ribonucleotide binding activity; and protein heterodimerization activity. Predicted to be involved in several processes, including cellular response to amino acid starvation; positive regulation of TORC1 signaling; and protein localization to lysosome. Predicted to be located in cytoplasm and nucleoplasm. Predicted to be part of FNIP-folliculin RagC/D GAP and Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosomal membrane and nucleus. Orthologous to human RRAGC (Ras related GTP binding C). PHENOTYPE: Mice homozygous for a hypomorphic allele show complete preweaning lethality, with partial embryonic observed at E13.5. Heterozygotes exhibit attenuated nutrient signaling and impaired B cell activation upon immunization but show normal longevity and normal age-dependent health decline. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
