| Primary Identifier | MGI:97912 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 19744 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables GTP binding activity and protein kinase binding activity. Involved in negative regulation of cold-induced thermogenesis and positive regulation of TORC1 signaling. Acts upstream of or within positive regulation of oligodendrocyte differentiation. Part of spliceosomal complex. Is active in Golgi membrane and synapse. Is expressed in chondrocranium bone; nervous system; nucleus pulposus; and sensory organ. Orthologous to human RHEB (Ras homolog, mTORC1 binding). PHENOTYPE: Mice homozygous for a null allele display embryonic lethality during organogenesis associated with impaired heart development. Mice homozygous for a conditional allele activated in the heart exhibit postnatal lethality due to impaired cardiac hypertrophic growth and sarcomere maturation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
