| First Author | Mao GE | Year | 2012 |
| Journal | Prostate | Volume | 72 |
| Issue | 10 | Pages | 1052-9 |
| PubMed ID | 22314496 | Mgi Jnum | J:320820 |
| Mgi Id | MGI:6879759 | Doi | 10.1002/pros.22496 |
| Citation | Mao GE, et al. (2012) A joint effect of new Western diet and retinoid X receptor alpha prostate-specific knockout with development of high-grade prostatic intraepithelial neoplasia in mice--a preliminary study. Prostate 72(10):1052-9 |
| abstractText | BACKGROUND: The "New Western-style Diet" (NWD) characterized by high in fat and low in fiber, vitamin D, calcium, and methyl donors--are considered as a risk factor for prostate cancer. Previous studies have shown that premalignant lesions of human prostate have decreased expression of the Retinoid X Receptor alpha (RXRalpha). This study was to determine the effect of diet in RXRalpha knockout mice in developing high-grade prostate intraepithelial neoplasia (mPIN). METHODS: Male mice (n = 54) with or without the RXRalpha prostate null mutation were fed either NWD or AIN-76A control diet for 10 months; prostates were harvested at 11 months of age and examined for prostate mPIN. RESULTS: mPIN was seen in 79% of RXRalpha prostate null mice fed NWD (n = 19), 30.8% RXRalpha prostate null mice fed AIN-76A (n = 13), 42.9% RXRalpha wild-type mice fed NWD (n = 14), and 12.5% RXRalpha wild-type mice fed AIN-76A (n = 8). Unconditional Logistic analysis showed a significant joint effect of NWD and RXRalpha status in developing mPIN 26.3 (95% CI: 2.5-280), but interaction was not significant owing to the small sample size 1.6 (0.09-27.7, P = 0.7441). CONCLUSION: This study provides preliminary data to support a joint RXRalpha-diet effect in prostate carcinogenesis. |
