| First Author | Ishii M | Year | 2015 |
| Journal | Cell Metab | Volume | 22 |
| Issue | 5 | Pages | 761-76 |
| PubMed ID | 26365177 | Mgi Jnum | J:228348 |
| Mgi Id | MGI:5706848 | Doi | 10.1016/j.cmet.2015.08.016 |
| Citation | Ishii M, et al. (2015) Metabolic and Non-Cognitive Manifestations of Alzheimer's Disease: The Hypothalamus as Both Culprit and Target of Pathology. Cell Metab 22(5):761-76 |
| abstractText | Alzheimer's disease (AD) is increasingly recognized as a complex neurodegenerative disease beginning decades prior to the cognitive decline. While cognitive deficits remain the cardinal manifestation of AD, metabolic and non-cognitive abnormalities, such as alterations in body weight and neuroendocrine functions, are also present, often preceding the cognitive decline. Furthermore, hypothalamic dysfunction can also be a driver of AD pathology. Here we offer a brief appraisal of hypothalamic dysfunction in AD and provide insight into an underappreciated dual role of the hypothalamus as both a culprit and target of AD pathology, as well as into new opportunities for therapeutic interventions and biomarker development. |
