| First Author | Tamura H | Year | 2001 |
| Journal | Blood | Volume | 97 |
| Issue | 6 | Pages | 1809-16 |
| PubMed ID | 11238124 | Mgi Jnum | J:68077 |
| Mgi Id | MGI:1932013 | Doi | 10.1182/blood.v97.6.1809 |
| Citation | Tamura H, et al. (2001) B7-H1 costimulation preferentially enhances CD28-independent T-helper cell function. Blood 97(6):1809-16 |
| abstractText | B7-H1 is a recently described B7-like molecule that costimulates T-cell growth and cytokine secretion without binding to CD28, cytotoxic T-lymphocyte antigen-4 (CTLA-4), and inducible costimulator (ICOS). In this report, a mouse homologue of human B7-H1 is identified, and its immunologic functions are studied in vitro and in vivo. Mouse B7-H1 shares 69% amino acid homology to the human counterpart. Similar to human B7-H1, mouse B7-H1 can be induced to express on macrophages, T cells, and B cells and to enhance T-cell proliferation and secretion of interleukin-10 (IL-10), interferon-gamma, and granulocyte-macrophage colony-stimulating factor but not IL-2 and IL-4. Furthermore, B7-H1 preferentially costimulates CD4(+) T cells independently of CD28 and enhances mixed lymphocyte responses to allogeneic antigens. In contrast to B7-1, expression of B7-H1 on murine P815 tumor cells by transfection fails to increase allogeneic and syngeneic cytolytic T-cell responses in vitro and in vivo. Administration of B7-H1Ig fusion protein, however, enhances keyhole limpet hemocyanin- specific T-cell proliferation and 2,4,6-trinitrophenyl-specific immunoglobulin G2a antibody production. The study thus identifies a unique costimulatory pathway that preferentially affects T-helper cell functions. (Blood. 2001;97:1809-1816) |
