Primary Identifier | MGI:2443111 | Organism | mouse, laboratory |
Chromosome | 14 | NCBI Gene Number | 239273 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable several functions, including ABC-type transporter activity; glutathione transmembrane transporter activity; and prostaglandin transmembrane transporter activity. Predicted to be involved in export across plasma membrane; organic anion transport; and positive regulation of smooth muscle cell proliferation. Predicted to act upstream of or within cilium assembly; lipid transport; and organic hydroxy compound transport. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)). PHENOTYPE: Homozygous null mice are viable and fertile. Homozygotes for one null allele display impaired organic anion transport in the blood-brain and blood-cerebrospinal fluid barriers and kidney. Homozygotes for a second null allele display hypoalgesia and abnormal PGE2 physiology. [provided by MGI curators] |