| Primary Identifier | MGI:2445153 | Organism | mouse, laboratory |
| Chromosome | 4 | NCBI Gene Number | 269582 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable DNA secondary structure binding activity and anaphase-promoting complex binding activity. Predicted to be involved in mitotic DNA replication checkpoint signaling and mitotic G2 DNA damage checkpoint signaling. Predicted to act upstream of or within DNA replication checkpoint signaling. Predicted to be located in Golgi apparatus and nucleoplasm. Is expressed in several structures, including alimentary system; brain ventricular layer; endocrine gland; genitourinary system; and immune system. Orthologous to human CLSPN (claspin). PHENOTYPE: Homozygous null mice show complete embryonic lethality during organogenesis. Heterozygous null mice exhibit reduced female fertility, develop lymphoid hyperplasia as they age, and show increased susceptibility to non-alcoholic fatty liver disease, and increased liver damage and tumorigenesis in the DEN model of hepatocellular carcinoma. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
