| First Author | Mishra PR | Year | 1983 |
| Journal | Brain Res | Volume | 282 |
| Issue | 2 | Pages | 193-6 |
| PubMed ID | 6831242 | Mgi Jnum | J:12729 |
| Mgi Id | MGI:60950 | Doi | 10.1016/0165-3806(83)90098-6 |
| Citation | Mishra PR, et al. (1983) DNA loss in the developing cerebellum of nervous mouse: a flow cytometric study. Brain Res 282(2):193-6 |
| abstractText | Flow-cytometry of cerebellar EGL cells of nervous (nr) mouse revealed a reduction in DNA quantity per cell accompanied by an increase in the DNA dispersion during 6-8 days of postnatal life. This loss of DNA is due to a partial degeneration of the cells of EGL during the first week of postnatal life. The surviving cells later on achieve a DNA content equivalent to their bone marrow cells. The flow-cytometric technique also facilitates an early detection of the homozygous nervous mutant, almost 2 weeks before the clinical manifestation of the disease, which to date was not possible. |
