| Type | MGI:General | Description | at 3 months, TEM revealed an accumulation of vacuolated structures, some containing partially degraded cytoplasmic material consistent with autophagic vacuoles, not observed in wild-type beta cells beta cells exhibit rounded mitochondria with a severely disordered and amorphous structure, including an increased number of distorted cristae and inclusions not observed in wild-type cells 3D EM reconstruction tomography showed accumulation of electron lucent vacuolated structures, including large interconnected vacuoles (likely dilated ER), and smaller spherical vacuoles (possibly endosomes) |
