| Primary Identifier | IPR039813 | Type | Family |
| Short Name | CXCL12 |
| description | CXCL12 (stromal cell-derived factor-1, SDF1) is a chemokine that regulates development in hematopoietic, cardiovascular and nervous systems, and also regulates diverse cell functions, including differentiation, immune synapse formation, proliferation and survival in the immune system []. CXCL12 has two known receptors, CXCR4 and ACKR3/RDC [, ]. Binding of CXCL12 to CXCR4 induces trimeric G protein signaling leading to activation of the Src, phosphoinositide-3 kinase (PI3K)/AKT, ERK, and JNK pathways, contributing to pro-inflammatory function such as protease production and cellular migration [, ].CXCL12 is constitutively expressed in many tissues. It may also be upregulated in the context of infection and inflammation, acting both as a homeostatic and inflammatory chemokine []. |
