| Primary Identifier | MGI:4836548 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Thy1-PSEN1*A246E)16-3Sqn |
| Strain of Origin | C57BL/6 x SJL | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The human Thy-1 promoter was used to drive expression of a presenilin cDNA containing a substitution encoding an A246E amino acid substitution. Four lines were examined for their ability to rescue phenotypic defects in presinilin deficient mice. Ability to rescue phenotype varied but line 16-3 was one of the better lines and was chosen as representative. |
