| Primary Identifier | MGI:1097689 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 13349 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable C-C chemokine binding activity. Acts upstream of or within inflammatory response and regulation of chemokine production. Predicted to be located in endosome and membrane. Is expressed in several structures, including genitourinary system; hemolymphoid system; lung; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Plasmodium vivax malaria and malaria. Orthologous to human ACKR1 (atypical chemokine receptor 1 (Duffy blood group)). PHENOTYPE: Homozygous null mutants are healthy, but erythrocytes lack CXC and CC chemokine-binding activity, such that when challenged with LPS result in increased inflammatory infiltrates in lung and liver. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
