| First Author | Wang ZG | Year | 1998 |
| Journal | Nat Genet | Volume | 20 |
| Issue | 3 | Pages | 266-72 |
| PubMed ID | 9806545 | Mgi Jnum | J:50588 |
| Mgi Id | MGI:1306978 | Doi | 10.1038/3073 |
| Citation | Wang ZG, et al. (1998) PML is essential for multiple apoptotic pathways [see comments]. Nat Genet 20(3):266-72 |
| abstractText | The PML gene of acute promyelocytic leukaemia (APL) encodes a cell growth and tumour suppressor, however, the mechanisms by which PML suppresses tumorigenesis are poorly understood. We show here that Pml is required for Fas- and caspase-dependent DNA-damage-induced apoptosis. We also found that Pml is essential for induction of programmed cell death by Fas, tumour necrosis factor alpha (TNF), ceramide and type I and II interferons (IFNs). As a result, Pml-/- mice and cells are protected from the lethal effects of ionizing radiation and anti-Fas antibody. Pml is required for caspase 1 and caspase 3 activation upon exposure to these stimuli. The PML-RAR alpha fusion protein of APL renders haemopoietic progenitor cells resistant to Fas-, TNF- and IFN-induced apoptosis with a lack of caspase 3 activation, thus acting as a Pml dominant-negative product. These results demonstrate that Pml is a mediator of multiple apoptotic signals, and implicate inhibition of apoptosis in the pathogenesis of APL. |
