| First Author | Schrauzer GN | Year | 1978 |
| Journal | Bioinorg Chem | Volume | 9 |
| Issue | 3 | Pages | 245-53 |
| PubMed ID | 698283 | Mgi Jnum | J:101551 |
| Mgi Id | MGI:3604254 | Doi | 10.1016/s0006-3061(78)80005-2 |
| Citation | Schrauzer GN, et al. (1978) Arsenic and cancer: effects of joint administration of arsenite and selenite on the genesis of mammary adenocarcinoma in inbred female C3H/St mice. Bioinorg Chem 9(3):245-53 |
| abstractText | The joint administration of 2 ppm of arsenic as arsenite and of 2 ppm of selenium as selenite in the drinking water of inbred female C3H/St mice increases the incidence of spontaneous mammary adenocarcinoma significantly over the simultaneous controls and animals receiving 2 ppm As as arsenite or 2 ppm Se as selenite alone, indicating that arsenic abolishes the anticarcinogenic effect of selenium. Arsenite caused a significant increase of the tumor growth rates and raised the incidence of multiple tumors. The tumor growth rates in the As-Se group were also increased, but the incidence of multiple tumors was lower than in the 2 ppm As group. |
