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Protein Coding Gene : Nisch nischarin
Primary Identifier  MGI:1928323 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  64652
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables integrin binding activity. Acts upstream of or within Rac protein signal transduction; actin cytoskeleton organization; and negative regulation of cell migration. Located in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and integumental system. Used to study otitis media. Human ortholog(s) of this gene implicated in congestive heart failure. Orthologous to human NISCH (nischarin).
PHENOTYPE: Mice homozygous for either a knock-out or hypomorphic allele exhibit hearing loss associated with increased susceptibility to otitis media. [provided by MGI curators]
  • synonyms:
  • MGI:3653500,
  • 1200007D05Rik,
  • AW494485,
  • Nisch,
  • MGI:1921365,
  • RIKEN cDNA 3202002H23 gene,
  • nischarin,
  • 3202002H23Rik,
  • expressed sequence AW494485,
  • edsn,
  • MGI:2145818,
  • edison,
  • RIKEN cDNA 1200007D05 gene,
  • MGI:1924216
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Trail: ProteinCodingGene

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