| First Author | Gao DM | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 7 | Pages | 1702-8 |
| PubMed ID | 16500646 | Mgi Jnum | J:107644 |
| Mgi Id | MGI:3621593 | Doi | 10.1016/j.febslet.2006.02.017 |
| Citation | Gao DM, et al. (2006) Expression of mouse liver receptor homologue 1 in embryonic stem cells is directed by a novel promoter. FEBS Lett 580(7):1702-8 |
| abstractText | Liver receptor homologue 1 (LRH-1) plays important roles in many physiological processes and embryogenesis. However, little is known about the developmental regulation of lrh-1 expression. We identified a novel transcript of mouse lrh-1 (mlrh-1v2) from embryonic stem (ES) cells. mlrh-1v2 is expressed throughout embryogenesis and in several adult tissues, while the known transcript (mlrh-1v1) appears later during embryogenesis. mlrh-1v2 expression is directed by a new promoter which displays a strong activity in ES cells. The generation of the new transcript is conserved in rats. The identification of novel mlrh-1 variant and promoter is critical for elucidating LRH-1 functions in development and adult tissues. |
