| First Author | McLean CS | Year | 1993 |
| Journal | J Gen Virol | Volume | 74 ( Pt 2) |
| Pages | 239-45 | PubMed ID | 8381463 |
| Mgi Jnum | J:15803 | Mgi Id | MGI:63914 |
| Doi | 10.1099/0022-1317-74-2-239 | Citation | McLean CS, et al. (1993) Delayed-type hypersensitivity response to the human papillomavirus type 16 E7 protein in a mouse model. J Gen Virol 74(Pt 2):239-45 |
| abstractText | To study the immune response to human papillomavirus type 16, a mouse model was developed using a mouse keratinocyte cell line expressing the E7 protein. This line was grafted onto syngeneic mice to form a differentiated epithelium, thus closely mimicking the natural infection. A delayed-type hypersensitivity response could be demonstrated after intradermal challenge with a vaccinia virus recombinant expressing the E7 protein. This response appeared to be specific for the E7 polypeptide and was mediated by CD4+ cells. |
