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Type  MGI:General Description  all mice treated with a low dose of retinoic acid at E9 die perinatally unlike similarly treated wild-type mice 50% of retinoic acid treated mice exhibit a loss of ossification centers in cervical vertebrae unlike in similarly treated wild-type mice 8 of 11 retinoic acid-treated mice lack the sixth vertebra unlike similarly treated wild-type mice sternum ossification centers in retinoic acid treated mice are shifted resulting in a crankshaft sternum unlike in similarly treated wild-type mice retinoic acid treated mice have cleft palates resulting in breathing difficulties and premature death unlike similarly treated wild-type mice treatment with folic acid does not improve incidence of spina bifida occulta