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Protein Coding Gene : Phc2 polyhomeotic 2

Primary Identifier  MGI:1860454 Organism  mouse, laboratory
Chromosome  4 NCBI Gene Number  54383
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable chromatin binding activity; histone binding activity; and identical protein binding activity. Acts upstream of or within spermatogenesis. Located in nucleus. Part of PRC1 complex and heterochromatin. Is expressed in several structures, including central nervous system and retina nuclear layer. Orthologous to human PHC2 (polyhomeotic homolog 2).
PHENOTYPE: Mice homozygous for a knock-out allele have normal skulls but exhibit posterior homeotic transformations of the axial skeleton. Cultured mouse embryonic fibroblasts show defects in proliferation and premature senescence. [provided by MGI curators]
  • synonyms:
  • Edr2,
  • DNA segment, Chr 4, ERATO Doi 810, expressed,
  • RIKEN cDNA D130050K19 gene,
  • AA415044,
  • Phc2,
  • MGI:2140153,
  • MGI:1289316,
  • D130050K19Rik,
  • early development regulator 2 (homolog of polyhomeotic 2),
  • Mph2,
  • polyhomeotic 2,
  • MGI:2441942,
  • D4Ertd810e,
  • expressed sequence AA415044

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

4 Involved In Mutations

0 Strain

0 Transcripts

2 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

13 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For