| Primary Identifier | MGI:2442988 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 211673 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable guanyl-nucleotide exchange factor activity; myosin binding activity; and protein kinase A regulatory subunit binding activity. Predicted to be involved in several processes, including negative regulation of actin filament polymerization; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of wound healing. Predicted to act upstream of with a positive effect on protein glycosylation. Predicted to act upstream of or within protein transport. Predicted to be located in several cellular components, including Golgi apparatus; nuclear lumen; and perinuclear region of cytoplasm. Predicted to be part of small nuclear ribonucleoprotein complex. Is expressed in brain. Orthologous to human ARFGEF1 (ADP ribosylation factor guanine nucleotide exchange factor 1). PHENOTYPE: Mice homozygous for a null allele exhibit neonatal lethality, absent gastric milk and decreased brain size with increased neuron apoptosis, abnormal axon guidance and hypersensitivity to glutamate. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
