| First Author | Wei K | Year | 2007 |
| Journal | Genesis | Volume | 45 |
| Issue | 6 | Pages | 382-90 |
| PubMed ID | 17523175 | Mgi Jnum | J:121871 |
| Mgi Id | MGI:3712581 | Doi | 10.1002/dvg.20304 |
| Citation | Wei K, et al. (2007) Neural crest cell deficiency of c-myc causes skull and hearing defects. Genesis 45(6):382-90 |
| abstractText | The proto-oncogene c-myc has a central role in multiple processes important for embryonic development, including cell proliferation, growth, apoptosis, and differentiation. We have investigated the role of c-myc in neural crest by using Wnt1-Cre-mediated deletion of a conditional mutation of the c-myc gene. c-myc deficiency in neural crest resulted in viable adult mice that have defects in coat color, skull frontal bone, and middle ear ossicle development. Physiological hearing studies demonstrated a significant hearing deficit in the mutant mice. In this report, we focus on the craniofacial and hearing defects. To further examine neural crest cells affected by c-myc deficiency, we fate mapped Wnt1-Cre expressing neural crest cells using the ROSA26 Cre reporter transgene. The phenotype obtained demonstrates the critical role that c-myc has in neural crest during craniofacial development as well as in providing a model for examining human congenital skull defects and deafness. genesis 45:382-390, 2007. Published 2007 Wiley-Liss, Inc. |
