| Primary Identifier | MGI:5538612 | Allele Type | Endonuclease-mediated |
| Attribute String | Null/knockout | Gene | Mlkl |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | TALENs targeting exon 1 induced a 2 bp deletion at the 52nd base of the coding region. This deletion results in a stop codon and premature truncation after glutamine 17 (p.C18*fs*1). Western blot analysis confirmed the absence of protein expression in mouse embryonic fibroblasts, bone marrow-derived macrophages (BMDMs), peritoneal macrophages, thymus, muscle, colon, intestine, heart, liver, spleen, lung, kidney and brain. |
