| Primary Identifier | MGI:2685385 | Organism | mouse, laboratory |
| Chromosome | 16 | NCBI Gene Number | 545156 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable enzyme binding activity and guanyl-nucleotide exchange factor activity. Acts upstream of or within several processes, including learning or memory; maternal behavior; and maternal process involved in parturition. Predicted to be located in several cellular components, including neuronal cell body; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be active in several cellular components, including glutamatergic synapse; postsynaptic density; and presynapse. Predicted to be extrinsic component of membrane. Is expressed in dorsal root ganglion and spinal cord. Human ortholog(s) of this gene implicated in cerebral atherosclerosis; cerebral infarction; and coronary artery disease. Orthologous to human KALRN (kalirin RhoGEF kinase). PHENOTYPE: Mice homozygous for a knock-out allele specific for isoform 7 exhibit decreased anxiety-related behavior, contextual conditioning, and synapse formation. Mice homozygous for another knock-out allele exhibit impaired AMPA-mediated synaptic currents and abnormal behavior. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
