| First Author | Angelillo-Scherrer A | Year | 2005 |
| Journal | J Clin Invest | Volume | 115 |
| Issue | 2 | Pages | 237-46 |
| PubMed ID | 15650770 | Mgi Jnum | J:95952 |
| Mgi Id | MGI:3528131 | Doi | 10.1172/JCI22079 |
| Citation | Angelillo-Scherrer A, et al. (2005) Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest 115(2):237-46 |
| abstractText | Mechanisms regulating thrombus stabilization remain largely unknown. Here, we report that loss of any 1 of the Gas6 receptors (Gas6-Rs), i.e., Tyro3, Axl, or Mer, or delivery of a soluble extracellular domain of Axl that traps Gas6 protects mice against life-threatening thrombosis. Loss of a Gas6-R does not prevent initial platelet aggregation but impairs subsequent stabilization of platelet aggregates, at least in part by reducing 'outside-in' signaling and platelet granule secretion. Gas6, through its receptors, activates PI3K and Akt and stimulates tyrosine phosphorylation of the beta3 integrin, thereby amplifying outside-in signaling via alphaIIbbeta3. Blocking the Gas6-R-alphaIIbbeta3 integrin cross-talk might be a novel approach to the reduction of thrombosis. |
