| First Author | Soysa NS | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 378 |
| Issue | 1 | Pages | 1-5 |
| PubMed ID | 18992710 | Mgi Jnum | J:143182 |
| Mgi Id | MGI:3823143 | Doi | 10.1016/j.bbrc.2008.10.146 |
| Citation | Soysa NS, et al. (2009) NF-kappaB functions in osteoclasts. Biochem Biophys Res Commun 378(1):1-5 |
| abstractText | NF-kappaB is a pleiotropic transcription factor, which regulates osteoclast formation, function, and survival. The finding that the deletion of both NF-kappaB p50 and p52 subunits resulted in osteopetrosis due to the absence of osteoclasts was followed by the observation that NF-kappaB is essential for RANK-expressing osteoclast precursors to differentiate into TRAP+ osteoclasts in response to RANKL and other osteoclastogenic cytokines. Thus, inhibitors of NF-kappaB should prevent osteoclast formation induced directly or indirectly by RANKL or TNF. In this mini review, we discuss the research findings that revealed essential roles of NF-kappaB signaling in osteoclasts. |
