| First Author | Kumar H | Year | 2006 |
| Journal | J Exp Med | Volume | 203 |
| Issue | 7 | Pages | 1795-803 |
| PubMed ID | 16785313 | Mgi Jnum | J:124405 |
| Mgi Id | MGI:3721477 | Doi | 10.1084/jem.20060792 |
| Citation | Kumar H, et al. (2006) Essential role of IPS-1 in innate immune responses against RNA viruses. J Exp Med 203(7):1795-803 |
| abstractText | IFN-beta promoter stimulator (IPS)-1 was recently identified as an adapter for retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (Mda5), which recognize distinct RNA viruses. Here we show the critical role of IPS-1 in antiviral responses in vivo. IPS-1-deficient mice showed severe defects in both RIG-I- and Mda5-mediated induction of type I interferon and inflammatory cytokines and were susceptible to RNA virus infection. RNA virus-induced interferon regulatory factor-3 and nuclear factor kappaB activation was also impaired in IPS-1-deficient cells. IPS-1, however, was not essential for the responses to either DNA virus or double-stranded B-DNA. Thus, IPS-1 is the sole adapter in both RIG-I and Mda5 signaling that mediates effective responses against a variety of RNA viruses. |
