| First Author | Prieschl EE | Year | 1996 |
| Journal | Gene | Volume | 169 |
| Issue | 2 | Pages | 215-8 |
| PubMed ID | 8647449 | Mgi Jnum | J:32109 |
| Mgi Id | MGI:79614 | Doi | 10.1016/0378-1119(95)00827-6 |
| Citation | Prieschl EE, et al. (1996) The murine homolog of TB2/DP1, a gene of the familial adenomatous polyposis (FAP) locus. Gene 169(2):215-8 |
| abstractText | The cDNA of the murine counterpart of the human TB2/DP1 (deleted in polyposis) gene, one of the six genes deleted in severe cases of familial adenomatous polyposis (FAP) disease, was isolated and analyzed. The murine transcript is 734-bp long and thereby considerably shorter than the 3100-bp human counterpart. This is due to a completely different 3' untranslated region in mouse which starts immediately after the translational stop codon, thereby deleting a RFLP (restriction-fragment length polymorphism) marker for this disease. The amino acid sequence, however, is 92% conserved between mouse and man. Triggering of murine mast cells by IgE plus antigen results in a decrease of TB2/DP1 mRNA up to 60% after 2 h implying a possible role of this gene in regulation of the allergic effector cell. Reverse transcription-polymerase chain reaction (RT-PCR) analysis shows an ubiquitous expression pattern in a number of mouse cell lines and tissues. |
