| First Author | Leitenberg D | Year | 1999 |
| Journal | Immunity | Volume | 10 |
| Issue | 6 | Pages | 701-11 |
| PubMed ID | 10403645 | Mgi Jnum | J:110516 |
| Mgi Id | MGI:3640438 | Doi | 10.1016/s1074-7613(00)80069-2 |
| Citation | Leitenberg D, et al. (1999) Biochemical association of CD45 with the T cell receptor complex: regulation by CD45 isoform and during T cell activation. Immunity 10(6):701-11 |
| abstractText | CD45 is the predominant transmembrane tyrosine phosphatase in lymphocytes and is required for the efficient induction of T cell receptor signaling and activation. However, the regulation of CD45 activity and substrate specificity are poorly understood. In the present study, we demonstrate a basal biochemical association of CD45 with the T cell receptor complex that is regulated in part by CD45 isoform expression. Further, maintenance of CD45/TCR association is differentially regulated following TCR ligation with peptide: a partial agonist peptide induces CD45/TCR dissociation while an agonist peptide promotes sustained association in a CD4-dependent manner. These data suggest that T cell receptor signaling pathways may be modulated by altering access of CD45 to TCR-associated substrates involved in T cell activation. |
