| First Author | Isa Y | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 373 |
| Issue | 3 | Pages | 429-34 |
| PubMed ID | 18577375 | Mgi Jnum | J:139172 |
| Mgi Id | MGI:3807423 | Doi | 10.1016/j.bbrc.2008.06.046 |
| Citation | Isa Y, et al. (2008) 6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes. Biochem Biophys Res Commun 373(3):429-34 |
| abstractText | In this study, we demonstrated that the two ginger-derived components have a potent and unique pharmacological function in 3T3-L1 adipocytes via different mechanisms. Both pretreatment of 6-shogaol (6S) and 6-gingerol (6G) significantly inhibited the tumor necrosis factor-alpha (TNF-alpha) mediated downregulation of the adiponectin expression in 3T3-L1 adipocytes. Our study demonstrate that (1) 6S functions as a PPARgamma agonist with its inhibitory mechanism due to the PPARgamma transactivation, and (2) 6G is not a PPARgamma agonist, but it is an effective inhibitor of TNF-alpha induced c-Jun-NH(2)-terminal kinase signaling activation and thus, its inhibitory mechanism is due to this inhibitory effect. |
