Primary Identifier | MGI:2137026 | Organism | mouse, laboratory |
Chromosome | 11 | NCBI Gene Number | 94045 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables extracellularly ATP-gated monoatomic cation channel activity. Acts upstream of or within excitatory postsynaptic potential and monoatomic cation transmembrane transport. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including forelimb bud; nervous system; neural ectoderm; olfactory epithelium; and retina. Orthologous to human P2RX5 (purinergic receptor P2X 5). PHENOTYPE: Homozygous mutant mice exhibit decreased peripheral blood CD8+ lymphocytes and elevated NK cells. Impaired learning/memory during trace aversive conditioning and increased exploratory behavior during open field testing is also seen. [provided by MGI curators] |