| First Author | Zhang J | Year | 2022 |
| Journal | iScience | Volume | 25 |
| Issue | 12 | Pages | 105620 |
| PubMed ID | 36465115 | Mgi Jnum | J:344162 |
| Mgi Id | MGI:7407777 | Doi | 10.1016/j.isci.2022.105620 |
| Citation | Zhang J, et al. (2022) TWIK-related acid-sensitive K(+) channel 2 promotes renal fibrosis by inducing cell-cycle arrest. iScience 25(12):105620 |
| abstractText | TWIK-related acid-sensitive K(+) channel-2 (TASK-2, encoded by Kcnk5) is essential in cell biological processes, by regulating transmembrane K(+) balance. In the present study, we aimed to clarify the role of TASK-2 in renal fibrosis and explore the underlying mechanism. We found that TASK-2 level was elevated in the renal tubular UUO- and UIR-induced renal fibrosis as well as in patients with renal tubulointerstitial fibrosis. Knockout of Kcnk5 or inhibition of TASK-2 in renal tubules attenuated G2/M cell-cycle arrest and alleviated renal fibrosis. Mechanistically, demethylase fat mass and obesity-associated protein (FTO) reduced N6-adenosine methylation (m6A) of Kcnk5 mRNA following renal fibrosis. FTO deficiency attenuated the upregulation of TASK-2 and renal fibrosis. The results demonstrated the crucial role of TASK-2 in renal fibrosis, which is conducive to a better understanding of the pathogenesis of renal fibrosis. TASK-2 may be a potential treatment strategy to alleviate the development of renal fibrosis. |
