| First Author | Van Snick J | Year | 1988 |
| Journal | Eur J Immunol | Volume | 18 |
| Issue | 2 | Pages | 193-7 |
| PubMed ID | 2965020 | Mgi Jnum | J:22957 |
| Mgi Id | MGI:70825 | Doi | 10.1002/eji.1830180202 |
| Citation | Van Snick J, et al. (1988) cDNA cloning of murine interleukin-HP1: homology with human interleukin 6. Eur J Immunol 18(2):193-7 |
| abstractText | Interleukin-HP1 (HP1) is a murine T cell-derived lymphokine, originally described as a growth factor for B cell hybridomas and plasmacytomas, that was recently shown to stimulate growth and differentiation of normal B and T lymphocytes. Here, we describe a cDNA for HP1 that was isolated from a library prepared using mRNA of a murine helper T cell clone activated with a clonotypic antibody. The cDNA, which hybridizes with a mRNA of approximately 1300 bp, encodes a polypeptide consisting of 211 amino acids with a typical signal sequence of 24 residues followed by 187 amino acids, which form the mature protein (Mr = 21,710). No N-glycosylation site but several potential O-glycosylation sites were identified in the predicted sequence. Comparison of the cDNA sequence of HP1 with that of human interleukin 6 disclosed a homology of 65% at the DNA level and of 42% at the protein level with a maximum of 57% for the segment spanning residues 42-102 of mature HP1. Considering the functional homology that was previously established between these two proteins, we therefore propose that HP1 be renamed murine interleukin 6. |
