Primary Identifier | MGI:3039582 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 381983 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable protein kinase activity. Predicted to act upstream of or within phosphorylation. Predicted to be located in Golgi apparatus; cell projection; and membrane. Is expressed in liver lobe and nervous system. Orthologous to human LMTK3 (lemur tyrosine kinase 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit pronounced behavioral abnormalities, including locomotor hyperactivity, reduced anxiety, and decreased depression-like behavior, an increased striatal dopamine turnover rate, and enhanced behavioral response to methylphenidate. [provided by MGI curators] |