| First Author | O'Donovan KJ | Year | 2014 |
| Journal | J Exp Med | Volume | 211 |
| Issue | 5 | Pages | 801-14 |
| PubMed ID | 24733831 | Mgi Jnum | J:213126 |
| Mgi Id | MGI:5582953 | Doi | 10.1084/jem.20131780 |
| Citation | O'Donovan KJ, et al. (2014) B-RAF kinase drives developmental axon growth and promotes axon regeneration in the injured mature CNS. J Exp Med 211(5):801-14 |
| abstractText | Activation of intrinsic growth programs that promote developmental axon growth may also facilitate axon regeneration in injured adult neurons. Here, we demonstrate that conditional activation of B-RAF kinase alone in mouse embryonic neurons is sufficient to drive the growth of long-range peripheral sensory axon projections in vivo in the absence of upstream neurotrophin signaling. We further show that activated B-RAF signaling enables robust regenerative growth of sensory axons into the spinal cord after a dorsal root crush as well as substantial axon regrowth in the crush-lesioned optic nerve. Finally, the combination of B-RAF gain-of-function and PTEN loss-of-function promotes optic nerve axon extension beyond what would be predicted for a simple additive effect. We conclude that cell-intrinsic RAF signaling is a crucial pathway promoting developmental and regenerative axon growth in the peripheral and central nervous systems. |
