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Publication : Murine bone morphogenetic protein-4 gene: existence of multiple promoters and exons for the 5'-untranslated region.

First Author  Kurihara T Year  1993
Journal  Biochem Biophys Res Commun Volume  192
Issue  3 Pages  1049-56
PubMed ID  8507180 Mgi Jnum  J:4969
Mgi Id  MGI:53448 Doi  10.1006/bbrc.1993.1523
Citation  Kurihara T, et al. (1993) Murine bone morphogenetic protein-4 gene: existence of multiple promoters and exons for the 5'-untranslated region. Biochem Biophys Res Commun 192(3):1049-56
abstractText  A murine genomic clone of about 16 kilobases encompassing putatively entire bone morphogenetic protein (BMP)-4 gene has been isolated. Comparison with the cDNA clones revealed the existence of at least five exons on the 3' side of the clone. There are two alternative transcriptional start sites, one is for the first exon the other for the second, the resulting exon organization in mRNA is I-III-IV-V and II-III-IV-V, respectively. The coding region is dispersed between exons IV and V. Both promoter regions carry no canonical TATA box but carry GC rich sequences.
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