Primary Identifier | MGI:2177949 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | F2 |
Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
Is Recombinase | false | Is Wild Type | false |
molecularNote | A neomycin selection cassette replaced a genomic DNA fragment that contains exons 7-11, which encode one of the kringle domains, the activation cleavage site and part of the active site. Western blot analysis on liver extracts derived from homozygous mice confirmed that no detectable protein was expressed from this allele. |