| Primary Identifier | MGI:1347078 | Organism | mouse, laboratory |
| Chromosome | 13 | NCBI Gene Number | 26385 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable G protein-coupled receptor kinase activity and beta-adrenergic receptor kinase activity. Predicted to be involved in desensitization of G protein-coupled receptor signaling pathway. Predicted to act upstream of or within Wnt signaling pathway. Predicted to be located in membrane. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; liver; lung; spleen; and submandibular gland primordium. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to human GRK6 (G protein-coupled receptor kinase 6). PHENOTYPE: Whereas, homozygous mutant mice are viable and show no gross anatomical or behavioral abnormalites under normal physiological conditions, they exhibit locomotor supersensitivity to psychostimulants including cocaine and amphetamine. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
