Primary Identifier | MGI:1197519 | Organism | mouse, laboratory |
Chromosome | 2 | NCBI Gene Number | 12125 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables microtubule binding activity; molecular adaptor activity; and protein kinase binding activity. Involved in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including apoptotic signaling pathway; hematopoietic or lymphoid organ development; and lymphocyte homeostasis. Located in membrane and mitochondrion. Part of Bcl-2 family protein complex. Is expressed in several structures, including hair outer root sheath; metanephros; neural tube; spleen; and trunk mesenchyme. Orthologous to human BCL2L11 (BCL2 like 11). PHENOTYPE: Consistent with this gene's role in hematopoietic homeostasis, homozygous null mutants accumulate lymphoid and myeloid cells and succumb to autoimmune kidney disease. [provided by MGI curators] |