| Primary Identifier | IPR032663 | Type | Family |
| Short Name | ATOH7 |
| description | Transcription factor ATOH7 (previously known as Protein atonal homologue 7, Atoh7, and Math5) is a basic helix-loop-helix transcription factor that is involved in early stages of retinal neurogenesis [, , ]. It is specifically expressed in the embryonic neural retina and is required for the genesis of retinal ganglion cells (RGCs) and optic nerves [].This entry also includes Xenopus atonal homologue 5 (Xath5), which is involved in the differentiation of retinal ganglion cells and olfactory receptor neurons [].The bHLH (basic Helix-Loop-Helix) proteins contain the bHLH domain that is approximately 60 amino acids long and consists of a DNA-binding basic region followed by two a-helices separated by a variable loop region (HLH). The HLH domain promotes dimerisation, allowing the formation of homo- or heterodimeric complexes between different family members. Many bHLH proteins have been shown to act as transcriptional regulators []. |
