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Publication : Common TLR5 mutations control cancer progression.

First Author  Pfirschke C Year  2015
Journal  Cancer Cell Volume  27
Issue  1 Pages  1-3
PubMed ID  25584886 Mgi Jnum  J:218897
Mgi Id  MGI:5619007 Doi  10.1016/j.ccell.2014.12.008
Citation  Pfirschke C, et al. (2015) Common TLR5 mutations control cancer progression. Cancer Cell 27(1):1-3
abstractText  The mechanisms regulating tumor-associated inflammation are incompletely understood. In this issue of Cancer Cell, Rutkowski and colleagues indicate that TLR5 signaling deficiency, which occurs in approximately 10% of the population, changes interactions with commensal microbiota and deregulates a cascade of inflammatory events that can suppress or accelerate extraintestinal cancers.
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