| Type | MGI:General | Description | some axons in brain and spinal cord are grossly dilated, having rounded contours often as large as neighboring cell bodies; numbers of dilated axons (axonopathy) is greater in homozygotes than heterozygous or wild-type littermates, or homozygous Tg(Thy1-MAPT)5Vln mice dilated axons in brain are most often observed in neocortex, hippocampus, and thalamus, and found mainly in proximal gray matter in spinal cord dilated axons are located primarily in gray matter, with some found in white matter fiber tracts at 8 weeks and 8 months of age, axons show prominent accumulation of neurofilaments, microtubules, mitochondria, endoplasmic reticulum, and vesicles |
