| Primary Identifier | MGI:1313302 | Organism | mouse, laboratory |
| Chromosome | 1 | NCBI Gene Number | 108000 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Predicted to enable DNA-binding transcription factor binding activity; dynein complex binding activity; and protein homodimerization activity. Acts upstream of or within regulation of striated muscle tissue development. Located in cytoskeleton and pronucleus. Part of ciliary transition fiber. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and limb. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in Stromme syndrome. Orthologous to human CENPF (centromere protein F). PHENOTYPE: Surprisingly, mice homozygous for any of three endonuclease-mediated mutations that specifically disrupt different domains of CENPF important for mitosis and mitochondrial regulation are viable, fertile and reach adulthood without any apparent phenotype. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
